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Virginia Wade defeated defending champion Billie Jean King in the final, 6–4, 6–2 to win the women's singles tennis title at the 1968 US Open. It was her first major singles title. This was the first edition of the US Open to be open to professional players, marking a period in tennis history known as the Open Era.
Seeds
The seeded players are listed below. Virginia Wade is the champion; others show the round in which they were eliminated.